Transmembrane Protein Evolution by Internal Gene Duplication
نویسندگان
چکیده
Recent studies reveal that transmenbrane (TM) topology (the number of TM segments (TMSs), the TMS position and the orientation of TMS to the membrane lipid bilayer) evolves by internal gene duplication [1, 6]. A large number of TM proteins, such as Bacteriorhodopsin, Na/Ca exchanger and the major facilitator superfamily, have been recognized to have internal repeats that presumably has arisen from the duplication event [5, 6, 7]. In this study, we search comprehensively for sequences with internal repeat by comparing partial sequences (PSs) within a single sequence in prokaryotic genomes, and investigate evolutionary pathways of TM topologies by analyzing duplication patterns obtained.
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